Future University In Egypt

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Staff Research

Hebatollah Atef Saad,Youmna Ibrahim,Mennatollah Atef

Paper Title : Thiazolo [4, 5-d] pyridazine analogues as a new class of dihydrofolate reductase (DHFR) inhibitors: Synthesis, biological evaluation and molecular modeling study.

Author : Hebatollah Atef Saad,Youmna Ibrahim,Mennatollah Atef

CoAuthors : Dalal A.Abou El Ellab,Deena S.Lasheen

Source : Bioorganic Chemistry

Date of Publication : 10/2017

Abstract : A new series of 1,3-thiazoles and thiazolo[4,5-d]pyridazine both bearing the 2-thioureido function were designed, synthesized and evaluated for their in vitro DHFR inhibition and antitumor activities. Compound 26 proved to be the most active DHFR inhibitor (IC50 of 0.06 μM). Compound 4, 20 and 21 showed in vitro antitumor activity against a collection of cancer cell lines. Compound 26 proved lethal to HS 578T breast cancer cell line with IC50 value of 0.8 μM, inducing cell cycle arrest and apoptosis. Molecular modeling studies concluded that recognition with key amino acids Phe 31 and Arg 22 is essential for DHFR binding. The obtained model could be useful for the development of new class of DHFR inhibitors.

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With the growing emphasis on collaborative and interdisciplinary science, Research Centers have become indispensable to highly ranked universities. They gain their importance from the outstanding role they play in enhancing the academic activities, in general, and post graduate reputation and scientific ranking in particular. Realizing this fact, Future University in Egypt (FUE) have decided and allocated sufficient funds and infrastructure to establish FUE Research Center (FUERC) having the following vision, mission, and goals
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Future University in Egypt’s Department of Continuing Education (DCE) is dedicated to bridging the gap between the capabilities
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The Future Factory for Industrial Training’s (FFIT) aim is to be recognized for its unique training facility as well as its advanced techniques. As a result, we established a training pharmaceutical plant, that provides an actual simulation of an industrial atmosphere with the processes and procedures that take place in the manufacturing world.
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FUE has maintained a highly reputable dental faculty over the years, therefore the development of the Dental Hospital is a step towards the FUE goal of providing the best dental academic programs
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