Future University In Egypt

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Staff Research

Marwa Raafat,Nada Anwar AbdelRazek

Paper Title : Diverse origins of microbial L-asparaginases and their current miscellaneous applications

Author : Marwa Raafat,Nada Anwar AbdelRazek

CoAuthors : Walid Faisal Elkhatib, Mohammad Aboulwafa

Source : Archives of Pharmaceutical Sciences Ain Shams University

Date of Publication : 04/2019

Abstract : L-asparaginase, also known as amidohydrolase, catalyzes the breakdown of asparagine into aspartic acid and ammonia. Due to its ability to inhibit the biosynthesis of protein lymphoblasts, it is used to treat acute lymphoblastic leukemia (ALL). It also has other applications in the food industry by preventing the formation of acrylamide. Different organisms including bacteria, fungi, actinomycetes, and plants produce L-asparaginase. This review highlights different applications of L-asparaginase in the industrial fields, the major sources of L-asparaginase, its immunological reactions and production techniques through the solid state (SSF) and submerged (SmF) fermentation as well as optimization of the production process.

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