Future University In Egypt (FUE)

Staff Research

Paper Title :
Author : Seham Elkheshen
CoAuthors : Nermeen A. Elkasabgy, Fatma S. Abdel-Salam, Emad B. Basalious, Mohammed S. Amer, Amany A. Mostafa
Source : International Journal of Pharmaceutics
Date of Publication : 11/2019
Abstract : Bone injury is very serious in elder people or osteoporotic patients. In-situ forming implants (IFI) for bone rebuilding are usually poly-lactic-co-glycolic acid (PLGA)-based, which have a burst release effect. This study aimed to prepare novel liquid lipid-based PLGA-IFI loaded with raloxifene hydrochloride for prolonged non-surgical treatment of bone injuries by applying solvent-induced phase inversion technique. Labrasol® and Maisine® were added to the selected IFI forming long lasting lipid-based IFI (LLL-IFI). The formulations were characterized by analysing their in-vitro drug release, solidification time, injectability, rheological properties, and DSC in addition to their morphological properties. Results revealed that the LLL-IFI composed of 10%w/v PLGA with a lactide to glycolide ratio of 75:25 with ester terminal and 10% Maisine® possessed the most sustained drug release and lowest burst effect, as well as delayed pore formation compared to its counterpart lacking Maisine®. The selected LLL-IFI and PLGA-IFI formulations were tested for their capability to enhance bone regeneration in bone injuries induced in rats. Both formulations succeeded in healing the bones completely with the superiority of LLL-IFI in the formation of well-organized bone structures lacking fibrous tissues. The results suggest that LLL-IFI and PLGA-IFI are innovative approaches for treating critical and non-critical sized bone injuries.
Download PDF
BACK
  • Research Centers

    With the growing emphasis on collaborative and interdisciplinary science, Research Centers have become indispensable to highly ranked universities. They gain their importance from the outstanding role they play in enhancing the academic activities, in general, and post graduate reputation and scientific ranking in particular. Realizing this fact, Future University in Egypt (FUE) have decided and allocated sufficient funds and infrastructure to establish FUE Research Center (FUERC) having the following vision, mission, and goals

    read more
  • Continuing Education

    Future University in Egypt’s Department of Continuing Education (DCE) is dedicated to bridging the gap between the capabilities

    read more
  • FUE Pharmaceutical Factory

    The Future Factory for Industrial Training’s (FFIT) aim is to be recognized for its unique training facility as well as its advanced techniques. As a result, we established a training pharmaceutical plant, that provides an actual simulation of an industrial atmosphere with the processes and procedures that take place in the manufacturing world.

    read more
  • FUE Dental Hospital

    FUE has maintained a highly reputable dental faculty over the years, therefore the development of the Dental Hospital is a step towards the FUE goal of providing the best dental academic programs

    read more
Community service unit at Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, launches Q&A about Covid-19.

Community service unit at Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, launches Q&A about Covid-19.

COVID-19 Awareness
FUEscientificJournals

VISIT FUE

Take a step to<br>Future<br>For a better future

Address

End of 90th St., Fifth Settlement,
New Cairo, Egypt

Hotline

Inside Egypt: 16383 (16FUE)

Outside Egypt: +20216383, +2026186100

Copyright © 2023 [Future University in Egypt]. All rights reserved.