Author : Eman Morgan,Mohamed Mohamed,Hayam Lotfy
CoAuthors : Yasmin Mohammed Fayez, Mohamed K. Abd El-Rahman
Source : Journal of the Electrochemical Society
Date of Publication : 07/2019
Abstract :
The possibility of obtaining continuous analytical signal excluding any pre-treatment of sample is the most environmental friendly method of analysis. In the current manuscript, a solid contact sensor was fabricated for dual purpose; firstly, determination of valaciclovir hydrochloride (VAL) in existence of its acid induced degradation product, Guanine (GUA) and secondly, real time acquisition of the dissolution profile from its pharmaceutical formulations (Valtrex) and (Valysernex). The sensing membrane was fabricated using a polyvinyl chloride (PVC), sodium tetraphenyl borate as a cation exchanger with bis (2-ethylhexyl) sebacate as a plasticizer. The proposed sensor displayed fast, stable Nernstian responses across VAL concentration range (1 × 10−5 M to 1 × 10−2 M). The opportunities of the proposed sensor with respect to other off-line classical techniques originates from being in-line, time saving, cost-effective, green and simple. ICH guidelines were followed to ensure validation of the proposed method concerning accuracy and precision.
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