Author : Ehab Rasmy
CoAuthors : Saly Sherif, Sabry Badawy
Source : Journal of Advanced Pharmaceutical Research
Date of Publication : 01/2013
Abstract :
Cubosomes are discrete, sub-micron, nanostructured particles of the bicontinuous cubic liquid crystalline phase.
Such novel particles are utilized to encapsulate guest molecules which are either hydrophilic, lipophilic or
amphiphilic, due to the compartmentalization of its structure. Cubosomes usually have been produced by means of
time-consuming methods involving high energy input “Top-down approach”. However, the application of high
energy is regarded as a barrier to temperature sensitive ingredients and is difficult to scale up. As a result, it was
useful to develop a process for producing cubosomes that requires no significant energy input as the “Bottom-up
approach”. The purpose of this study was to evaluate the efficiency of both approaches in fabrication of cubosomes.
Dispersions were characterized by visual inspection, optical and transmission electron microscopy, encapsulation
efficiency and in-vitro release. Results indicated that the bottom-up approach using less energy input was more
efficient in generation of smaller cubosomes with higher encapsulation efficiency and slower release rate
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