Author : Amr Mohamed Badawy
CoAuthors : Ali K. Attia,*a Amr M. Badawyb and Samr G. Abd-Elhamida
Source : Royal society of Chemistry
Date of Publication : 06/2016
Abstract :
A gold nanoparticles modified carbon paste electrode (AuCPE) was used to study the electrochemical
behavior of sparfloxacin HCl (SPAR) and besifloxacin HCl (BESI) using cyclic and differential pulse
voltammetry modes in the presence of micellar medium. Effect of different surfactants on peak current
was studied in Britton–Robinson buffer solution of pH 2. Sodium dodecyl sulphate is the optimum
surfactant based on the enhancement of the peak current. The modified electrode shows highly
sensitive sensing giving an excellent response for SPAR and BESI. The peak current varied linearly over
the concentration ranges from 1.1 107 mol L1 to 3.3 106 mol L1 and from 2.2 106 mol L1 to
5.5 105 mol L1 with determination coefficients of 0.9976 and 0.9984 in case of SPAR and BESI,
respectively. The recoveries and the relative standard deviations were found in the following ranges:
99.97–101.4% and 0.63–1.48% for SPAR and 99.89–101.1% and 0.85–1.76% for BESI. The detections
limits were 2.87 108 and 3.76 107 mol L1 for SPAR and BESI, respectively. The proposed method
has been successfully applied to determine SPAR and BESI in biological fluids.
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