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Staff Research

Ramzia Ibrahim

Paper Title : Simultaneous determination of Metformin, Vildagliptin, and Vildagliptin impurity in bulk, tablet, and human plasma using UPLC-MS/MS

Author : Ramzia Ibrahim

CoAuthors : El Kady, EF; Farouk, F; Azzazy, HME

Source : PBA-RDPA

Date of Publication : 01/2013

Abstract : Metformin (M) and vildagliptin (V) are co-administered in tablets used for the management of patients with type II diabetes mellitus. We have developed an UPLC-MS/MS method for simultaneous determination of M, V, and vildagliptin impurity (VI) in bulk, tablet, and plasma. The method employed electro-spray positive ionization and multiple-reaction monitoring mode. The m/z values for M, V, and VI were 130: 71, 60; 304: 154, 97; and 168: 151, 93.1 [M+ H]+; respectively. Chromatographic elution was achieved in 2 min on an UPLC C-18 ...

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Research Centers

With the growing emphasis on collaborative and interdisciplinary science, Research Centers have become indispensable to highly ranked universities. They gain their importance from the outstanding role they play in enhancing the academic activities, in general, and post graduate reputation and scientific ranking in particular. Realizing this fact, Future University in Egypt (FUE) have decided and allocated sufficient funds and infrastructure to establish FUE Research Center (FUERC) having the following vision, mission, and goals
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