Future University In Egypt (FUE)

Staff Research

Paper Title :
Author : Mona El Assal
Source : International
Date of Publication : 01/2014
Abstract : ABSTRACT: Background and Objective: Renal failure patients were treated with linezolid (LZD) for proven or suspected infections by multi-resistant Gram-positive cocci. The aim of this study was to determine if dose adjustment of LZD is needed as a function of renal impairment or not, especially that a significant component of LZD is eliminated unchanged in urine. Methods: The single dose pharmacokinetics of LZD was investigated. Eighteen non-infected male subjects with various degrees of renal impairment ranged from normal to severe chronic impairment were enrolled, including end-stage renal disease (ESRD) patients maintained on hemodialysis (HD). LZD was administered as a single oral 600mg dose, and blood samples were drawn at different times and analysed by a validated HPLC assay method. Plasma profiles were evaluated by non-compartmental and compartmental approaches. Results and Discussion: A similar rate and extent of LZD absorption and elimination and comparable body exposure was observed in both healthy subjects and acute renal failure patients. The extent of LZD exposure was significantly increased by 3-fold in ESRD patients in their off-dialysis day. Furthermore, the t1/2 and MRT values were significantly increased by ~5- and 3-fold, respectively. The Vd/F values of LZD did not change with renal function. A significant decrease in CL/F by ~3-fold was observed in ESRD patients in their off-dialysis day however, CL/F was significantly increased by ~4-fold during HD. Approximately half of the administered LZD dose was removed during the HD session in these selected cohorts of ESRD patients. LZD was generally well tolerated. Conclusions: The dose of LZD did not need to be adjusted for patients with acute renal dysfunction or ESRD on HD. One of the twice-daily doses should be administered after the dialysis session because almost half of the LZD dose was substantially removed by HD. During the first three dialysis sessions of the treatment course, to avoid potentially ineffective therapy, a supplemental dose of LZD might be given if necessary or the dose of LZD should be administered 4 h before the beginning of the HD session. This was to keep LZD levels above the MIC for the organism causing the infection being treated.
Download PDF
BACK
  • Research Centers

    With the growing emphasis on collaborative and interdisciplinary science, Research Centers have become indispensable to highly ranked universities. They gain their importance from the outstanding role they play in enhancing the academic activities, in general, and post graduate reputation and scientific ranking in particular. Realizing this fact, Future University in Egypt (FUE) have decided and allocated sufficient funds and infrastructure to establish FUE Research Center (FUERC) having the following vision, mission, and goals

    read more
  • Continuing Education

    Future University in Egypt’s Department of Continuing Education (DCE) is dedicated to bridging the gap between the capabilities

    read more
  • FUE Pharmaceutical Factory

    The Future Factory for Industrial Training’s (FFIT) aim is to be recognized for its unique training facility as well as its advanced techniques. As a result, we established a training pharmaceutical plant, that provides an actual simulation of an industrial atmosphere with the processes and procedures that take place in the manufacturing world.

    read more
  • FUE Dental Hospital

    FUE has maintained a highly reputable dental faculty over the years, therefore the development of the Dental Hospital is a step towards the FUE goal of providing the best dental academic programs

    read more
Community service unit at Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, launches Q&A about Covid-19.

Community service unit at Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, launches Q&A about Covid-19.

COVID-19 Awareness
FUEscientificJournals

VISIT FUE

Take a step to<br>Future<br>For a better future

Address

End of 90th St., Fifth Settlement,
New Cairo, Egypt

Hotline

Inside Egypt: 16383 (16FUE)

Outside Egypt: +20216383, +2026186100

Copyright © 2023 [Future University in Egypt]. All rights reserved.